Dennings continued working on television, guest-starring on Without a Trace as a teen whose boyfriend goes missing, and on Less than Perfect in 2003.
In February 2004, she was cast in a pilot for CBS titled Sudbury, about a family of modern-day witches, based on the 1998 film Practical Magic, but the series was not picked up.
Actors Sam Rockwell and Josh Hartnett were involved, but the project was not greenlit because of its controversial subject matter of nuclear war.
In 2009, Dennings appeared in The Answer Man, a story about a celebrity author whose manifestos become a sort of new Bible.
Dennings starred in the drama film To Write Love on Her Arms (originally titled Renee) in 2012, with Chad Michael Murray and Rupert Friend.
She played Renee Yohe, a Florida teenager who struggled with substance abuse and self-injury, and who inspired the founding of the nonprofit organization To Write Love on Her Arms.
When you see a “due out” date it means that is the date by which the animal can be either pulled for adoption, rescue or put on the TBD list.Dennings made her professional debut with an appearance on HBO's Sex and the City in 2000, in the episode "Hot Child in the City", playing an obnoxious 13-year-old who hires Samantha to handle publicity for her bat mitzvah.She then starred on the short-lived WB sitcom Raising Dad from 2001 to 2002 as Sarah, a 15-year-old raised by her widowed father (Bob Saget), with a pre-teen sister (Brie Larson).After making her acting debut in an episode of the HBO dramedy series Sex and the City, Dennings has since appeared in films including The 40-Year-Old Virgin (2005), Big Momma's House 2 (2006), Charlie Bartlett (2007), The House Bunny (2008), Nick and Norah's Infinite Playlist (2008), Defendor (2009), Thor (2011) and Thor: The Dark World (2013).From 2011 to 2017, she starred alongside Beth Behrs in the CBS sitcom 2 Broke Girls.